在多发性硬化症中，HLA - D分型与Dw2相关以及对单纯疱疹（I型）抗原缺乏免疫反应。
HLA-D typing with an association of Dw2 and absent immune responses towards herpes simplex (type i) antigen in multiple sclerosis.
作者信息
Paty D W, Cousin H K, Stiller C R, Boucher D W, Furesz J, Warren K G, Marchuk L, Dossetor J B
出版信息
Transplant Proc. 1977 Dec;9(4):1845-8.
PMID:203060
Abstract
We have confirmed that HLA-Dw2 is increased in MS patients to 47% (normals 20%). Lymphocyte transformation and antibody studies with herpes simplex antigen show that many of the DW2-positive MS patients have low or absent responses. The association of low responses to HSV and the presence of Dw2 is statistically significant at a p value less than 0.01.
摘要
我们已经证实，HLA - Dw2在多发性硬化症患者中的比例增加到了47%（正常人中为20%）。针对单纯疱疹抗原的淋巴细胞转化和抗体研究表明，许多DW2阳性的多发性硬化症患者反应低下或无反应。对单纯疱疹病毒反应低下与Dw2存在之间的关联在p值小于0.01时具有统计学意义。
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