Department of Surgery, St. Elisabeth Hospital, P.O. Box 90151, 5000 LC, Tilburg, The Netherlands.
World J Surg. 2010 Jul;34(7):1453-60. doi: 10.1007/s00268-010-0526-0.
Quality of Life (QoL) is an important outcome measure in oncology. To assess the influence of surgical treatment and personality on QoL in women with breast cancer, a longitudinal prospective cohort study was done.
Women (n = 222) completed questionnaires concerning QoL (WHOQOL 100) and personality (NEO-FFI and STAI) prior to the diagnosis of breast cancer and 1, 3, 6, and 12 months after diagnosis and treatment. One hundred five women were treated with breast-conserving therapy (BCT) and 117 women underwent mastectomy (MTC).
The two treatment groups did not differ on overall QoL. At all measurement times the influence of trait anxiety on overall QoL was substantial in the BCT group. Women with a high score on trait anxiety were seven times more likely to have a low overall QoL 1 year after BCT. In the MTC group overall QoL was influenced mainly by neuroticism.
Personality, especially trait anxiety and neuroticism, determined patients' overall QoL scores. Women with an anxious personality fared worse concerning QoL after breast conserving therapy.
生活质量（QoL）是肿瘤学中的一个重要的结果衡量标准。为了评估手术治疗和人格对乳腺癌女性生活质量的影响，进行了一项前瞻性队列研究。
女性（n=222）在乳腺癌诊断前以及诊断和治疗后 1、3、6 和 12 个月完成了生活质量（WHOQOL 100）和人格（NEO-FFI 和 STAI）问卷。105 名女性接受了保乳治疗（BCT），117 名女性接受了乳房切除术（MTC）。
两组治疗方法在总体生活质量上没有差异。在所有测量时间点，特质焦虑对 BCT 组的总体生活质量都有很大影响。特质焦虑得分高的女性在 BCT 治疗 1 年后生活质量总体较低的可能性是其他人的七倍。在 MTC 组中，总体生活质量主要受神经质的影响。
人格，特别是特质焦虑和神经质，决定了患者的总体生活质量评分。具有焦虑人格的女性在接受保乳治疗后生活质量更差。
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