Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Biomed Microdevices. 2010 Aug;12(4):665-71. doi: 10.1007/s10544-010-9419-0.
An intradermal microdelivery system comprising a wafer having 150-mum long microneedles and an applicator was used for controlled release of insulin. Insulin was topically applied on microneedle-pretreated skin. In vitro percutaneous studies showed that the penetration amount of FITC-Insulin following microneedle pretreatment was enhanced significantly and continued to increase for several hours after the removal of donor phase. In vivo studies on diabetic rats confirmed that the pharmacodynamic profile of percutaneously administrated regular insulin was smooth, with the duration of action comparable to that of subcutaneously injected biphasic insulin. The effects of insulin concentration, duration and area of microneedle treatment on blood glucose lowering were studied in vivo. The results indicated that the duration of microneedle treatment and insulin concentration were key influencing factors to optimize blood glucose control. The extent of blood glucose lowering was in proportion to the area of microneedle treatment.
一种包含 150 微米长的微针和给药器的皮内微输送系统被用于控制胰岛素的释放。胰岛素被局部应用于微针预处理过的皮肤。体外经皮研究表明，在微针预处理后，FITC-胰岛素的渗透量显著增加，并在去除供体相后数小时内持续增加。在糖尿病大鼠的体内研究证实，经皮给予常规胰岛素的药效学特征平稳，作用持续时间与皮下注射双相胰岛素相当。体内研究了微针处理的胰岛素浓度、时间和面积对降血糖的影响。结果表明，微针处理的时间和胰岛素浓度是优化血糖控制的关键影响因素。血糖降低的程度与微针处理的面积成正比。
