Paton Robin W, Fox Anna E, Foster Anne, Fehily Max
From Blackburn Royal Hospital, East Lancashire Hospitals NHS Trust, United Kingdom.
Acta Orthop Belg. 2010 Feb;76(1):86-9.
This study looks at the changing incidence and aetiology of congenital talipes equinovarus due to the recent population changes within the area. Between 1st June 1992 and the 31st May 2006, 83 consecutive children (121 feet) born with fixed talipes equinovarus (TEV) were assessed and treated (an incidence of 1.6 per 1000 live births) in an observational longitudinal cohort study assessing associated factors. There were 17 syndromal cases in the fixed group (20.8%), 6 cases of non-syndromal distal arthrogryposis (7.2%), and a strong family history in 12 cases (14.5%). This study would suggest that genetic and primary causes of fixed TEV are more common than previously considered. Many of the primary aetiologies were diagnosed months or years after birth.
本研究着眼于由于该地区近期的人口变化,先天性马蹄内翻足的发病率和病因的变化。在1992年6月1日至2006年5月31日期间,在一项评估相关因素的观察性纵向队列研究中,对83例连续出生的患有固定性马蹄内翻足(TEV)的儿童(121只脚)进行了评估和治疗(每1000例活产中有1.6例的发病率)。固定组中有17例综合征病例(20.8%),6例非综合征性远端关节挛缩症病例(7.2%),12例有强烈家族史(14.5%)。本研究表明,固定性TEV的遗传和原发性病因比以前认为的更为常见。许多原发性病因在出生后数月或数年才被诊断出来。