先天性马蹄内翻足：西西里岛的一项流行病学研究。
Congenital talipes equinovarus: an epidemiological study in Sicily.
机构信息
Orthopaedics Clinic, University of Catania, Italy.
出版信息
Acta Orthop. 2012 Jun;83(3):294-8. doi: 10.3109/17453674.2012.678797. Epub 2012 Apr 11.
BACKGROUND AND PURPOSE
Congenital talipes equinovarus (clubfoot) can present in 2 forms: "syndromic", in which other malformations exist, and the more common "idiopathic" form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the Sicilian population, looking for potential etiological factors.
PATIENTS AND METHODS
Among the 801,324 live births recorded between January 1991 and December 2004, 827 cases were registered (560 males; M/F sex ratio: 2.1). Control infants were randomly selected from a historical cohort of live births without any major congenital malformations.
RESULTS
A positive family history of clubfoot, gender, and maternal smoking were found to be risk factors for clubfoot. Patients with clubfoot were born most frequently during the period January-March. No association was found between clubfoot and reproductive history, peri-conceptional maternal drug exposure, maternal education, or ethnicity.
INTERPRETATION
Our findings emphasize the importance of birth defects surveillance programs and their usefulness in investigating potential risk factors.
背景与目的
先天性马蹄内翻足（马蹄足）有两种表现形式：“综合征型”，即存在其他畸形，以及更为常见的“特发性”形式，即不存在其他相关畸形。我们分析了西西里人口中先天性马蹄内翻足的流行病学情况，寻找潜在的病因因素。
患者与方法
在 1991 年 1 月至 2004 年 12 月期间记录的 801,324 例活产儿中，共登记了 827 例（男性 560 例；男女比例：2.1）。对照组婴儿是从无重大先天性畸形的活产儿历史队列中随机选择的。
结果
家族性马蹄足病史、性别和母亲吸烟被认为是马蹄足的危险因素。马蹄足患者出生最多的时期是 1 月至 3 月。马蹄足与生育史、围孕期母亲药物暴露、母亲教育程度或种族无关。
结论
我们的研究结果强调了出生缺陷监测计划的重要性及其在调查潜在危险因素方面的作用。
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