Kim Dong Hoon, Kwon Mi Seon
Department of Pathology, Dankook University College of Medicine, 16-5 Anseo-dong, Cheonan, Chungnam 330-715, Republic of Korea.
Acta Cytol. 2010 Jan-Feb;54(1):55-9. doi: 10.1159/000324967.
To determine whether CD63, p63 and CD56 are useful in the diagnostic evaluation of cytologic samples of pulmonary malignancy.
We explored the utility of using a panel of 3 antibodies, CD63, p63 and CD56, for the diagnosis of lung cancer in cytologic samples consisting of 40 cases of cell block sections and previously Papanicolaou-stained cytologic smear slides.
The positive rates for CD63, p63 and CD56 were as follows: adenocarcinoma (18/19), (0/19), (0/19), for small cell lung carcinoma (3/8), (0/8), (8/8), and for squamous cell carcinoma (0/13), (12/13), (0/13). All p63 positive cases were squamous cell carcinoma, and all CD56 positive cases were small cell lung carcinoma. CD63 was positive in the majority of adenocarcinomas.
The panel of CD63, p63 and CD56 appears to be useful in the diagnostic evaluation of cytologic samples of pulmonary malignancy.
确定CD63、p63和CD56是否有助于肺恶性肿瘤细胞学样本的诊断评估。
我们探讨了使用一组3种抗体（CD63、p63和CD56）对由40例细胞块切片和先前巴氏染色的细胞学涂片载玻片组成的细胞学样本进行肺癌诊断的效用。
CD63、p63和CD56的阳性率如下：腺癌分别为（18/19）、（0/19）、（0/19）；小细胞肺癌分别为（3/8）、（0/8）、（8/8）；鳞状细胞癌分别为（0/13）、（12/13）、（0/13）。所有p63阳性病例均为鳞状细胞癌，所有CD56阳性病例均为小细胞肺癌。大多数腺癌中CD63呈阳性。
CD63、p63和CD56这一组抗体似乎有助于肺恶性肿瘤细胞学样本的诊断评估。
