Schramm Henning M
Institute Hiscia, Society for Cancer Research, CH-4144 Arlesheim/Switzerland.
J Cancer. 2014 Jan 15;5(2):125-32. doi: 10.7150/jca.8242. eCollection 2014.
Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in both types of cell lineages. Moreover, cancer cells express multiple specific markers of the myeloid lineages thus giving rise to the hypothesis that the transition of cancer cells may be from epithelial to myeloid cells and not to mesenchymal cells. This interpretation would better explain why cancer cells, often already in their primary cancer site, frequently show properties common to those of macrophages, platelets and pre-/osteoclasts.
癌细胞表达上皮标志物,在发生恶性进展时,它们可能会表达间充质细胞类型的标志物。因此,假定癌细胞发生了上皮-间充质转化。然而,间充质标志物同样可以很好地被解释为髓系标志物,因为它们在这两种细胞谱系中都很常见。此外,癌细胞表达多种髓系谱系的特异性标志物,从而产生了一种假说,即癌细胞的转化可能是从上皮细胞到髓系细胞,而不是到间充质细胞。这种解释将更好地说明为什么癌细胞,通常在其原发癌部位就经常表现出与巨噬细胞、血小板和前破骨细胞/破骨细胞共有的特性。