Experimental Pathology Laboratories, Research Triangle Park, North Carolina, USA.
Drug Chem Toxicol. 2010 Apr;33(2):131-7. doi: 10.3109/01480541003667610.
Perfluorooctanoate (PFO) is a perfluorinated carboxylate that is widely distributed in the environment. A 2-year chronic study was conducted in rats fed either 30 or 300 ppm of ammonium perfluorooctanoate (APFO). To investigate the possible relationship of APFO exposure to proliferative mammary lesions, a Pathology Working Group (PWG) review of the original slides was performed. The consensus reached by the PWG was that the incidence of mammary-gland neoplasms was not affected by chronic dietary administration of APFO. Therefore, feeding female rats up to 300 ppm of APFO resulted in no increase in proliferative lesions of the mammary tissue.
全氟辛烷酸（PFO）是一种全氟羧酸，广泛分布于环境中。对大鼠进行了为期 2 年的慢性研究，这些大鼠分别喂食 30 或 300ppm 的全氟辛烷酸铵（APFO）。为了研究 APFO 暴露与增生性乳腺病变之间的可能关系，对原始切片进行了病理学工作组（PWG）的审查。PWG 达成的共识是，慢性饮食摄入 APFO 不会影响乳腺肿瘤的发病率。因此，给雌性大鼠喂食高达 300ppm 的 APFO 不会导致乳腺组织增生性病变的增加。
