Staples R E, Burgess B A, Kerns W D
Fundam Appl Toxicol. 1984 Jun;4(3 Pt 1):429-40. doi: 10.1016/0272-0590(84)90200-8.
Ammonium perfluorooctanoate (APFO, greater than 95% pure) was administered to Sprague-Dawley rats from Days 6 through 15 of gestation by inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 1, 10, and 25 mg/m3, or by gavage at 100 mg/kg body wt/day in corn oil. Maternal deaths occurred in the groups given the highest level of APFO by each route and overt toxicity was evident among the surviving dams of these groups and among those of the 10-mg/m3 group. The fetuses were examined for external, visceral, and skeletal alterations and for APFO-related macroscopic and microscopic alterations of the eyes. In the postpartum period, pups from additional control and experimental dams were examined externally and ophthalmoscopically, and the usual fertility and viability indices were calculated. A teratogenic response was not demonstrated. Toxic effects on the conceptus were noted only in the groups given the highest level of APFO by each route. Hence, APFO was not demonstrated to represent a unique hazard to the conceptus of the rat.
全氟辛酸铵（APFO，纯度大于95%）在妊娠第6天至第15天，通过吸入粉尘（全身暴露），以0、0.1、1、10和25毫克/立方米的浓度，每天6小时给予斯普拉格-道利大鼠，或以玉米油为溶剂，按100毫克/千克体重/天的剂量经口灌胃给予大鼠。通过每种途径给予最高剂量APFO的组中出现了母体死亡，在这些组以及10毫克/立方米组的存活母鼠中明显出现了明显的毒性。对胎儿进行了外部、内脏和骨骼改变以及与APFO相关的眼部宏观和微观改变的检查。在产后阶段，对来自额外对照和实验母鼠的幼崽进行了外部和眼底镜检查，并计算了通常的生育力和活力指数。未显示致畸反应。仅在通过每种途径给予最高剂量APFO的组中观察到对胎儿的毒性作用。因此，未证明APFO对大鼠胎儿具有独特危害。
