UGT1A1 基因中的遗传多态性与高加索男性前列腺癌风险。
Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men.
机构信息
University of Thessaly, School of Medicine, Department of Urology, Mezourlo, Larissa, Greece.
出版信息
Cancer Epidemiol. 2010 Jun;34(3):345-9. doi: 10.1016/j.canep.2010.02.009. Epub 2010 Mar 21.
BACKGROUND
Catechol-estrogen metabolites can induce carcinogenesis by acting as endogenous tumor initiators. Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is a main metabolic pathway of estrogen detoxification in steroid target tissues, such as the prostate. The aim of our study was to investigate the possible correlation between UGT1A1 promoter gene polymorphisms and prostate cancer risk.
PATIENTS AND METHODS
129 patients with prostate cancer and 260 healthy controls were included in our study. A(TA)TAA promoter polymorphism of UGT1A1 gene was studied using the Fragment Analysis Software of an automated DNA sequencer and three genotypes (homozygous 7/7, heterozygous 6/7 and normal homozygous 6/6) were identified.
RESULTS
No significant differences were observed between the cancer group and controls regarding the genotyping distribution of the three UGT1A1 promoter genotypes (P>0.05). Also, no association was found between overall disease risk and the presence of the polymorphic homozygous genotype (TA(7)/TA(7) vs TA(6)/TA(7)+TA(6)/TA(6)) (P=0.18). In addition, no association was revealed between UGT1A1 genotype distribution and Gleason score (P=0.55).
CONCLUSION
Our data suggest that the TA repeat polymorphism of UGT1A1 gene does not seem to alter prostate cancer risk susceptibility in Caucasian men.
背景
儿茶酚雌激素代谢物可以作为内源性肿瘤启动子诱导致癌作用。在甾体靶组织如前列腺中，雌激素的解毒主要通过 UDP-葡萄糖醛酸基转移酶 1A1（UGT1A1）酶介导的葡萄糖醛酸化途径进行。本研究旨在探讨 UGT1A1 启动子基因多态性与前列腺癌风险之间的可能相关性。
患者与方法
本研究纳入了 129 例前列腺癌患者和 260 例健康对照者。采用自动化 DNA 测序仪的 Fragment Analysis Software 研究 UGT1A1 基因的（TA）TAA 启动子多态性，并确定了三种基因型（纯合子 7/7、杂合子 6/7 和正常纯合子 6/6）。
结果
癌症组与对照组在三种 UGT1A1 启动子基因型的基因分型分布方面无显著差异（P＞0.05）。此外，多态性纯合子（TA（7）/TA（7）与 TA（6）/TA（7）+TA（6）/TA（6））的存在与总体疾病风险之间也未发现相关性（P=0.18）。此外，UGT1A1 基因型分布与 Gleason 评分之间也未显示出相关性（P=0.55）。
结论
我们的数据表明，UGT1A1 基因 TA 重复多态性似乎不会改变高加索男性患前列腺癌的风险易感性。
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