接种物、pH 值和阳离子对 fidaxomicin（OPT-80，PAR-101）体外抗艰难梭菌活性的影响。
Effects of inoculum, pH, and cations on the in vitro activity of fidaxomicin (OPT-80, PAR-101) against Clostridium difficile.
机构信息
Department of Biology, Optimer Pharmaceuticals, Inc., San Diego, CA 92121, USA.
出版信息
Antimicrob Agents Chemother. 2010 Jun;54(6):2674-6. doi: 10.1128/AAC.01842-09. Epub 2010 Mar 22.
Abstract
The effects of the inoculum, pH, cation concentrations, and different lots of commercial media on the in vitro susceptibility of Clostridium difficile to fidaxomicin were examined. Of the factors evaluated, only pH alterations influenced the activity of fidaxomicin against C. difficile, noticeably reducing its activity at higher pH (> or =7.9).
摘要
检测了接种物、pH 值、阳离子浓度和不同批次商业培养基对艰难梭菌体外对非达霉素敏感性的影响。在所评估的因素中，只有 pH 值的改变影响了非达霉素对艰难梭菌的活性，在较高的 pH 值（≥7.9）时明显降低了其活性。
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