Department of Endocrinology and Thyroid Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, India.
Indian Pediatr. 2010 Sep;47(9):761-9. doi: 10.1007/s13312-010-0116-0. Epub 2010 Jan 15.
To determine the efficacy of supplementation with oral vitamin D₃ (cholecalciferol) on bone mineral biochemical parameters of school-going girls.
Government school (government-aided) and Private school (fee paying) in Delhi.
Randomized controlled trial.
Cholecalciferol granules (60,000 IU) orally with water, either once in two months (two-monthly D₃ group) or once a month (one-monthly D₃ group) for one year.
290 healthy schoolgirls (6-17 y), 124 from lower socioeconomic strata (LSES) (attending government schools) and 166 from upper socioeconomic strata (USES) (attending private schools).
Serum 25(OH)D, calcium, phosphorus, parathyroid hormone, and alkaline phosphatase levels at 6 and 12 months after start of supplementation.
At baseline, 93.7% schoolgirls were vitamin D deficient [25(OH)D<50 nmol/L]. While significant increase in serum calcium and decrease in alkaline phosphatase levels was noted in both groups with both interventions, PTH response was inconsistent. In LSES subjects, two-monthly D₃ and one-monthly D₃ supplementation resulted in a significant increase in serum 25(OH)D levels by 8.3 nmol/L and 11.0 nmol/L, respectively at 6 months (P<0.05). Similarly, the increase in the two intervention arms in USES subjects was 10.5 nmol/L and 16.0 nmol/L, respectively (P<0.05). In both groups, this increase in serum 25(OH)D levels persisted at 12 months (P<0.05). Despite supplementation with 60,000 IU of Vitamin D₃ (monthly or two-monthly), only 47% were vitamin D sufficient at the end of one year.
60,000 IU of cholecalciferol, monthly or two-monthly, resulted in a significant increase in serum 25(OH)D levels in vitamin D deficient schoolgirls.
确定口服维生素 D₃（胆钙化醇）补充剂对在校女生骨矿物质生化参数的疗效。
德里的政府学校（政府资助）和私立学校（收费）。
随机对照试验。
胆钙化醇颗粒（60000IU）口服用水，每两个月一次（两月一次 D₃ 组）或每月一次（一月一次 D₃ 组），持续一年。
290 名健康女学生（6-17 岁），124 名来自较低社会经济阶层（LSES）（就读于政府学校）和 166 名来自较高社会经济阶层（USES）（就读于私立学校）。
开始补充后 6 个月和 12 个月时血清 25（OH）D、钙、磷、甲状旁腺激素和碱性磷酸酶水平。
在基线时，93.7%的女学生维生素 D 缺乏[25（OH）D<50nmol/L]。虽然两种干预措施都能显著提高两组血清钙水平并降低碱性磷酸酶水平，但甲状旁腺激素的反应不一致。在 LSES 受试者中，两月一次 D₃ 和一月一次 D₃ 补充分别使血清 25（OH）D 水平在 6 个月时显著增加 8.3nmol/L 和 11.0nmol/L（P<0.05）。同样，两种干预组在 USES 受试者中的增加量分别为 10.5nmol/L 和 16.0nmol/L（P<0.05）。在两组中，血清 25（OH）D 水平的这种增加在 12 个月时持续存在（P<0.05）。尽管补充了 60000IU 的维生素 D₃（每月或每两个月），但只有 47%的人在一年后维生素 D 充足。
每月或每两个月口服 60000IU 的胆钙化醇可显著提高维生素 D 缺乏的女学生血清 25（OH）D 水平。
