Jung A G, Bertsch H P, Schoen M P, Lippert U
Klinik für Dermatologie, Venerologie und Allergologie/Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany.
Hautarzt. 2010 Jun;61(6):514-7. doi: 10.1007/s00105-010-1924-9.
A 31-year-old woman presented with progressive deep linear induration on her lower abdomen, forearms and thighs. These symptoms developed three years after allogenic stem cell transplantation. Furthermore, the patient showed multiple hypopigmented lichenoid papules on the extensor surfaces of the forearms consistent with lichen sclerosus. Histological analysis of a biopsy specimen from her left thigh showed dermal sclerosis extending into the fascia, thus establishing the diagnosis of a rare combination of superficial and deep sclerodermoid chronic graft-versus-host disease. After 7 cycles of extracorporeal photopheresis, a marked resolution of the indurations and a reduction of the modified Rodnan skin score from 12 to 7 were noted.
一名31岁女性患者，下腹部、前臂和大腿出现进行性深部线性硬结。这些症状在异基因干细胞移植三年后出现。此外，患者前臂伸侧有多个色素减退的苔藓样丘疹，符合硬化性苔藓表现。对其左大腿活检标本进行组织学分析，显示真皮硬化延伸至筋膜，从而确诊为浅表和深部硬皮病样慢性移植物抗宿主病这一罕见组合。经过7个周期的体外光化学疗法后，硬结明显消退，改良罗德南皮肤评分从12分降至7分。
