Service de Dermatologie du CHU de Nancy, Hôpital Brabois, Vandoeuvre Les Nancy, France.
Photodermatol Photoimmunol Photomed. 2013 Jun;29(3):160-3. doi: 10.1111/phpp.12041.
Lichen sclerosus et atrophicus (LSA) is an inflammatory disease that affects the genitals, which was first described by Hallopeau in 1887 and is of unknown etiology. Only 15% of patients have an associated extra-genital form, and 2.5% have an isolated extra-genital form. LSA treatment remains poorly codified and mostly empirical. Here, we report a case of LSA, of mainly cutaneous form, which was effectively treated using extracorporeal photochemotherapy (ECP). Remission was achieved quickly, after the fourth session, with excellent treatment tolerance. ECP is now recognized as an effective treatment for erosive lichen planus, graft-versus-host disease (GVHD), and scleroderma. Thus, we began ECP treatment for our cases of LSA based on clinical and/or anatomopathological similarities between LSA and these commonly ECP-treated disorders. The fact that ECP is effective in LSA, GVHD, erosive lichen planus, and scleroderma strengthen the hypothesis that there is a common link between these four conditions.
萎缩性硬化性苔藓（LSA）是一种影响生殖器的炎症性疾病，于 1887 年由 Hallopeau 首次描述，病因不明。只有 15%的患者有相关的生殖器外表现，2.5%的患者有孤立的生殖器外表现。LSA 的治疗仍未得到很好的规范，大多是经验性的。在这里，我们报告了一例主要为皮肤形式的 LSA 病例，使用体外光化学疗法（ECP）有效治疗。第四次治疗后，病情迅速缓解，治疗耐受性良好。ECP 现在被认为是治疗糜烂性扁平苔藓、移植物抗宿主病（GVHD）和硬皮病的有效方法。因此，我们根据 LSA 与这些常见的 ECP 治疗疾病之间的临床和/或解剖病理学相似性，开始对 LSA 患者进行 ECP 治疗。ECP 在 LSA、GVHD、糜烂性扁平苔藓和硬皮病中的有效性证实了这四种疾病之间存在共同联系的假设。
