Varian Ltd., 6 Mead Road, Yarnton, Oxford OX5 1QU, UK.
Magn Reson Chem. 2010 May;48(5):333-6. doi: 10.1002/mrc.2595.
Three important NMR pulse sequences, INADEQUATE, HSQC and three-dimensional HMBC have been combined into a single entity called high-resolution Parallel Acquisition NMR: an All-in-one Combination of Experimental Applications (HR-PANACEA) to provide reliable structural information about a small molecule in a single measurement. This exploits a recent instrumental development that permits simultaneous acquisition of signals from several nuclear species, using multiple receivers. Where high-precision values of the long-range heteronuclear splittings are important, selected regions of a large experimental data matrix are extracted and examined with the highest possible resolution. The J-doubling technique is then applied to derive precise values for these couplings. As proof of principle, the method is applied to the molecule of methyl salicylate, confirming the expected conformation of the C-O-H moiety.
三种重要的 NMR 脉冲序列，即 INADEQUATE、HSQC 和三维 HMBC，已被组合成一个单一实体，称为高分辨率平行采集 NMR：一种用于提供小分子结构信息的实验应用的一体式组合（HR-PANACEA），可在单次测量中提供可靠的结构信息。这利用了最近的仪器发展，允许使用多个接收器同时采集来自几种核物种的信号。在需要高精度长程异核分裂值的情况下，从大实验数据矩阵中提取选定区域，并以尽可能高的分辨率进行检查。然后应用 J 倍增技术得出这些耦合的精确值。作为原理验证，该方法应用于水杨酸甲酯分子，证实了 C-O-H 部分的预期构象。
