Hughes D A, Beattie T J, Murphy A V
Renal Unit, Royal Hospital for Sick Children, Glasgow.
Scott Med J. 1991 Feb;36(1):9-12. doi: 10.1177/003693309103600105.
Seventy-nine children with the Haemolytic Uraemic Syndrome were referred to our unit between 1972 and 1988. The typical summer peak incidence was seen. A diarrhoeal prodrome occurred in 71 (90%). Fifty-nine (75%) required dialysis and 74 (94%) blood transfusion. Extra-renal disease was documented: neurological 32 (40%); abdominal 11 (14%); diabetes mellitus one case. Fifty-one (61%) had acute hypertension. The acute mortality rate was 9%. Children with neurological features had greater biochemical disturbances and longer duration of dialysis. Fifty-nine children were followed for a mean 47.4 months. Forty-four (75%) are healthy. Nine (15%) have renal impairment, two have proteinuria, one hypertension and one has a residual hemiparesis. There were two late deaths. Presence of acute neurological features increased risk of early death or survival with sequelae. Prolonged dialysis was significantly associated with poorer outcome. However, there were no reliable early indicators of poor prognosis.
1972年至1988年间，79名溶血尿毒综合征患儿被转诊至我院。观察到典型的夏季发病高峰。71例（90%）有腹泻前驱症状。59例（75%）需要透析，74例（94%）需要输血。记录到肾外疾病：神经病变32例（40%）；腹部病变11例（14%）；糖尿病1例。51例（61%）有急性高血压。急性死亡率为9%。有神经症状的患儿生化紊乱更严重，透析时间更长。59名患儿平均随访47.4个月。44例（75%）健康。9例（15%）有肾功能损害，2例有蛋白尿，1例有高血压，1例有残留偏瘫。有2例晚期死亡。急性神经症状的出现增加了早期死亡或存活伴后遗症的风险。延长透析时间与较差的预后显著相关。然而，没有可靠的早期预后指标。
