Barratt T M, Kasidas G P, Murdoch I, Rose G A
Department of Paediatric Nephrology, Institute of Child Health, London.
Arch Dis Child. 1991 Apr;66(4):501-3. doi: 10.1136/adc.66.4.501.
The diagnosis of primary hyperoxaluria in young children is hampered by the lack of a reliable reference range for urinary oxalate excretion, especially in infants. We present data on urinary oxalate and glycolate excretion in 137 normal children, on the plasma oxalate concentration in 33 normal children and 53 with chronic renal failure, and on amniotic fluid oxalate concentration in 63 uncomplicated pregnancies. The urinary oxalate:creatinine molar ratios were log normally distributed: mean (range) values were less than 1 year 0.061 (0.015-0.26), 1-5 years 0.036 (0.011-0.12), 5-12 years 0.030 (0.0059-0.15), and greater than 12 years 0.013 (0.0021-0.083). Geometric mean (range) plasma oxalate concentration in the normal children was 1.53 (0.78-3.02) mumols/l and was independent of age. The mean (SD) plasma oxalate: creatinine molar ratio in these normal children and 50 with chronic renal failure was 0.033 (0.013), and was independent of age and renal function. Mean (SD) amniotic fluid oxalate concentration was 19.0 (4.3) mumols/l.
幼儿原发性高草酸尿症的诊断因缺乏可靠的尿草酸排泄参考范围而受阻，尤其是在婴儿中。我们提供了137名正常儿童的尿草酸和乙醇酸排泄数据、33名正常儿童和53名慢性肾衰竭儿童的血浆草酸浓度数据，以及63例无并发症妊娠的羊水草酸浓度数据。尿草酸：肌酐摩尔比呈对数正态分布：小于1岁儿童的均值（范围）为0.061（0.015 - 0.26），1 - 5岁儿童为0.036（0.011 - 0.12），5 - 12岁儿童为0.030（0.0059 - 0.15），大于12岁儿童为0.013（0.0021 - 0.083）。正常儿童血浆草酸浓度的几何均值（范围）为1.53（0.78 - 3.02）μmol/L，且与年龄无关。这些正常儿童和50名慢性肾衰竭儿童的血浆草酸：肌酐摩尔比均值（标准差）为0.033（0.013），且与年龄和肾功能无关。羊水草酸浓度均值（标准差）为19.0（4.3）μmol/L。
