Cederholm B, Linne T, Wieslander J, Bygren P, Heinegård D
Department of Nephrology, University Hospital of Lund, Sweden.
Pediatr Nephrol. 1991 Mar;5(2):200-4. doi: 10.1007/BF01095952.
We have previously reported the presence of circulating IgA-fibronectin complexes in adult patients with primary IgA nephropathy. In the present study five children were serially investigated during the early course of IgA nephropathy and Henoch-Schönlein glomerulonephritis. Using affinity chromatography procedures and enzyme-linked immuno-sorbent assay, IgA, IgG and IgM in complex with fibronectin were repeatedly demonstrated during the follow-up period in both groups of patients. Most patients had, at the same time, IgA, IgG, as well as IgM deposits in the glomerular mesangium. The simultaneous presence of IgA and IgG in complexes purified from serum was furthermore demonstrated. The results are thus in contrast to the findings in adults with IgA nephropathy, in whom the immunoglobulin-fibronectin complexes only contained IgA. Whether this reflects different subgroups of patients or a different pathophysiology in children and adults remains to be elucidated.
我们之前报道过，在原发性IgA肾病成年患者中存在循环IgA-纤连蛋白复合物。在本研究中，对5名儿童在IgA肾病和过敏性紫癜性肾小球肾炎病程早期进行了连续观察。采用亲和层析法和酶联免疫吸附测定法，在两组患者的随访期间均反复检测到与纤连蛋白结合的IgA、IgG和IgM。大多数患者同时在肾小球系膜中有IgA、IgG以及IgM沉积。此外，还证实了从血清中纯化的复合物中同时存在IgA和IgG。因此，这些结果与IgA肾病成年患者的发现形成对比，后者的免疫球蛋白-纤连蛋白复合物仅含有IgA。这是反映了不同的患者亚组，还是儿童和成人不同的病理生理学，仍有待阐明。
