Linné T, Aperia A, Broberger O, Bergstrand A, Bohman S O, Wasserman J
Acta Paediatr Scand. 1983 Jan;72(1):97-104. doi: 10.1111/j.1651-2227.1983.tb09671.x.
Renal function studies were performed in 18 subjects in different stages of Henoch-Schönlein glomerulonephritis (HS GN). Nine children were serially investigated, and nine adolescents or young adults, who were considered to have clinically recovered, were investigated only once, 10.5-14 years after the onset. Inulin and PAH clearance, as well as sodium excretion, were determined during hydropenia (HP) and 3% volume expansion (VE) with isotonic saline. In most patients in the former group a renal biopsy was performed during the first investigation and again one year later. The early disturbances in renal function resembled those we have found in other types of GN. The GFR was normal during HP or after VE in most cases one year after the onset. The natriuretic response to VE was decreased in most patients initially, and this was found to persist in half of the patients 2-3 years after the onset. Pathological urinalyses then indicated disturbances in the renal handling of sodium. A reduced capacity to excrete sodium, however, did not seem to be of prognostic significance since all patients, except one who developed renal insufficiency and hypertension, had normal urinalyses and blood pressure six years after the onset. This study provides no evidence that subjects with previous HS GN will later develop impaired renal function or be predisposed to hypertension.
对18例不同阶段的过敏性紫癜性肾小球肾炎（HS GN）患者进行了肾功能研究。对9名儿童进行了系列研究，另外9名青少年或年轻成人被认为已临床康复，在发病10.5 - 14年后仅进行了一次研究。在禁水（HP）和用等渗盐水进行3%容量扩张（VE）期间，测定菊粉和对氨基马尿酸清除率以及钠排泄。在前一组的大多数患者中，首次研究时进行了肾活检，一年后再次进行。早期肾功能紊乱与我们在其他类型的GN中发现的情况相似。发病一年后，大多数情况下，HP期间或VE后肾小球滤过率（GFR）正常。大多数患者最初对VE的利钠反应降低，并且发现发病2 - 3年后，一半的患者这种情况仍持续存在。此时的病理尿检表明肾脏对钠的处理存在紊乱。然而，钠排泄能力降低似乎没有预后意义，因为除了一名发展为肾功能不全和高血压的患者外，所有患者在发病六年时尿检和血压均正常。本研究没有提供证据表明既往患有HS GN的患者日后会出现肾功能受损或易患高血压。
