Matl I, Kaslíková J, Jirka J
III. interní výzkumná základna, Institutu klinické a experimentálni medicíny, Praha.
Cas Lek Cesk. 1991 Mar 22;130(12):364-6.
Forty-five patients after transplantation of the kidney from a dead donor were treated by a triple combination of cyclosporin A, azathioprine and prednisone. In patients where during the first two days after transplantation the function of the graft was not restored, cyclosporin A was reduced and treatment supplemented by a combination of four by prophylactic administration of ATG for a period of 7 days. A total of 18 patients had a complete prophylactic dose of ATG. The results in this group were compared with a historical comparable group of 27 subjects treated only with the triple combination of drugs without reduction of cyclosporin A. In patients treated with ATG the mean initial function of the graft was reduced only insignificantly and the one-year survival of the graft was only insignificantly better than in the control group. During the first two months after transplantation there were significantly more leucopenic episodes in patients treated with ATG, however, no direct relationship with the latter was proved. The number of infectious complications in these patients was lower than in the control group.
45例接受死体供肾移植的患者采用环孢素A、硫唑嘌呤和泼尼松三联疗法进行治疗。对于移植后前两天移植肾功能未恢复的患者，减少环孢素A用量，并通过预防性给予抗胸腺细胞球蛋白（ATG）联合用药补充治疗7天。共有18例患者接受了完整的ATG预防剂量。将该组结果与27例仅接受三联药物治疗且未减少环孢素A用量的历史可比组进行比较。接受ATG治疗的患者中，移植物的平均初始功能仅略有降低，移植物的一年生存率仅略高于对照组。然而，移植后的前两个月，接受ATG治疗的患者白细胞减少发作明显更多，但未证明与ATG有直接关系。这些患者的感染并发症数量低于对照组。
