Hosemann W, Göde U, Länger F, Wigand M E
HNO-Klinik der Universität Erlangen-Nürnberg.
HNO. 1991 Feb;39(2):48-54.
A model of wound healing in the maxillary antrum of the rabbit was developed. The regeneration of standardized circular mucosal defects 4 mm in diameter was studied using conventional histology and serial sections as well as three-dimensional histomorphological analysis. Wound closure started by migration of epithelium; 24 h later mitoses were seen. 120 h after creation of the wound the granulation tissue covering the wound surface started to become hyperplastic, and bone apposition with formation of osteoid occurred. Systemic application of prednisolone i.m. (2 mg/kg per day) and topical administration of dexpanthenol-ointment (5%) resulted in an acceleration of the late epithelial wound closure together with a reduction of hyperplastic granulation tissue. Epidermal growth factor, applied locally, had no significant effect. The proposed animal model permits additional quantitative evaluation of postoperative treatment modalities.
建立了兔上颌窦伤口愈合模型。使用传统组织学、连续切片以及三维组织形态学分析，研究了直径4mm的标准化圆形黏膜缺损的再生情况。伤口闭合始于上皮迁移；24小时后可见有丝分裂。伤口形成120小时后，覆盖伤口表面的肉芽组织开始增生，并出现类骨质形成的骨附着。肌肉注射泼尼松龙（每天2mg/kg）及局部应用泛醇软膏（5%）可加速上皮伤口的后期闭合，同时减少增生性肉芽组织。局部应用表皮生长因子无显著效果。所提出的动物模型允许对术后治疗方式进行额外的定量评估。
