Mösges Ralph, Shah-Hosseini Kija, Hucke Hans-Peter, Joisten Marie-Josefine
Faculty of Medicine, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.
GASD mbH, Neuss, Germany.
Adv Ther. 2017 Aug;34(8):1850-1858. doi: 10.1007/s12325-017-0581-0. Epub 2017 Jul 10.
Nasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, we could demonstrate that the benefit of added dexpanthenol appears as early as on the third day of the combined application of xylometazoline and dexpanthenol in terms of complete or near-to-complete freedom from symptoms. After 5 days, 47% of the patients were cured under the combined treatment compared with only 1% under xylometazoline monotherapy. These data show that the addition of dexpanthenol to an alpha-sympathomimetic nasal spray not only improves its tolerability but also further increases its effectiveness and leads to expedited cure.
Klosterfrau Healthcare Group.
鼻塞是急性鼻炎最困扰人的症状。含有α-拟交感神经药（如羟甲唑啉和赛洛唑啉）的鼻减充血剂喷雾剂起效迅速。然而，随着反复使用，这种效果会降低，而且鼻黏膜的纤毛功能实际上会瘫痪。泛醇可促进细胞增殖并保护上皮细胞。将这两种药物联合使用已证明对急性鼻炎症状有有益的协同作用。在一项包括152名患者的大规模双盲、活性对照研究的事后分析中，我们可以证明，在联合使用赛洛唑啉和泛醇的第三天，就出现了添加泛醇的益处，即完全或几乎完全没有症状。5天后，联合治疗组47%的患者治愈，而赛洛唑啉单药治疗组仅1%的患者治愈。这些数据表明，在α-拟交感神经药鼻喷雾剂中添加泛醇不仅提高了其耐受性，还进一步提高了其有效性，并加快了治愈速度。
克洛斯特frau医疗集团。
