Kutcher G J, Burman C, Brewster L, Goitein M, Mohan R
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):137-46. doi: 10.1016/0360-3016(91)90173-2.
New tools are needed to help in evaluating 3-D treatment plans because of the large volume of data. One technique which may prove useful is the application of complication probability calculations. A method of calculating complication probabilities for inhomogeneously irradiated normal tissues is presented in this paper. The method uses clinical estimates of tolerance doses for a few discreet conditions of uniform partial organ irradiation, an empirical fit of a continuous function to these data, and a technique (the effective volume method) for transforming nonuniform dose-volume histograms into equivalent uniform histograms. The behavior of the effective volume histogram reduction method for various boundary conditions is reviewed. The use of complication probabilities in evaluating treatment plans is presented, using examples from an NCI 3-D treatment planning contract.
由于数据量庞大，需要新的工具来辅助评估三维治疗计划。一种可能有用的技术是应用并发症概率计算。本文提出了一种计算非均匀照射正常组织并发症概率的方法。该方法使用了在均匀局部器官照射的少数离散条件下的耐受剂量临床估计值，对这些数据进行连续函数的经验拟合，以及一种将非均匀剂量体积直方图转换为等效均匀直方图的技术（有效体积法）。回顾了有效体积直方图缩减方法在各种边界条件下的行为。通过美国国立癌症研究所三维治疗计划合同中的例子，介绍了并发症概率在评估治疗计划中的应用。
