Najwa A R, Sengupta Jayasree, Ghosh D
Department of Physiology, All India Institute of Medical Sciences, New Delhi - 110 029.
Indian J Physiol Pharmacol. 2009 Jul-Sep;53(3):197-208.
Time-synchronous development of endometrium and embryo under adequate progesterone dominance is considered integral to the process of blastocyst implantation in the human. It now appears that hypothesis-driven and candidate-based deductive approach fails to explain this complex control process. We propose a systems biology approach to elucidate the control process underlying the physiological basis of successful interfacing between embryo and endometrium towards blastocyst implantation. Elucidation of the time course pattern of transcriptomics involved in the process of blastocyst implantation in mid-luteal phase endometrium with and without progesterone dominance, as well as, with and without viable embryo shall elaborate upon the polygenic and multifactorial nature of the process of blastocyst implantation. Accordingly, a large scale homeodynamic model of hierarchical arrangement of functional networks of regulatory genomic expressional elements at the level of endometrial receptivity shall emerge. It is anticipated that such a systems biology approach shall provide an integrated picture of the process and shall also open up novel areas of basic, strategic and translational research in the biology of blastocyst implantation.
在足够的孕酮主导下，子宫内膜与胚胎的同步发育被认为是人类囊胚着床过程中不可或缺的一部分。现在看来，基于假设和候选基因的演绎方法无法解释这个复杂的控制过程。我们提出一种系统生物学方法，以阐明胚胎与子宫内膜成功对接以实现囊胚着床的生理基础背后的控制过程。阐明在黄体中期子宫内膜中，有或没有孕酮主导以及有或没有活胚胎的情况下，囊胚着床过程中涉及的转录组学的时间进程模式，将详细说明囊胚着床过程的多基因和多因素性质。相应地，将出现一个关于子宫内膜容受性水平上调控基因组表达元件功能网络层次排列的大规模动态模型。预计这种系统生物学方法将提供该过程的综合图景，还将为囊胚着床生物学的基础、战略和转化研究开辟新的领域。
