Rea R F, Hamdan M, Clary M P, Randels M J, Dayton P J, Strauss R G
Department of Internal Medicine, University of Iowa, Iowa City 52242.
J Appl Physiol (1985). 1991 Mar;70(3):1401-5. doi: 10.1152/jappl.1991.70.3.1401.
We compared changes in muscle sympathetic nerve activity (SNA) during graded lower body negative pressure (LBNP) and 450 ml of hemorrhage in nine healthy volunteers. During LBNP, central venous pressure (CVP) decreased from 6.1 +/- 0.4 to 4.5 +/- 0.5 (LBNP -5 mmHg), 3.4 +/- 0.6 (LBNP -10 mmHg), and 2.3 +/- 0.6 mmHg (LBNP -15 mmHg), and there were progressive increases in SNA at each level of LBNP. The slope relating percent change in SNA to change in CVP during LBNP (mean +/- SE) was 27 +/- 11%/mmHg. Hemorrhage of 450 ml at a mean rate of 71 +/- 5 ml/min decreased CVP from 6.1 +/- 0.5 to 3.7 +/- 0.5 mmHg and increased SNA by 47 +/- 11%. The increase in SNA during hemorrhage was not significantly different from the increase in SNA predicted by the slope relating percent change in SNA to change in CVP during LBNP. These data show that nonhypotensive hemorrhage causes sympathoexcitation and that sympathetic responses to LBNP and nonhypotensive hemorrhage are similar in humans.
我们比较了9名健康志愿者在分级下肢负压（LBNP）和450毫升出血过程中肌肉交感神经活动（SNA）的变化。在LBNP期间，中心静脉压（CVP）从6.1±0.4降至4.5±0.5（LBNP -5 mmHg）、3.4±0.6（LBNP -10 mmHg）和2.3±0.6 mmHg（LBNP -15 mmHg），并且在每个LBNP水平SNA都有逐渐增加。LBNP期间SNA百分比变化与CVP变化的相关斜率（平均值±标准误）为27±11%/mmHg。以平均71±5毫升/分钟的速率出血450毫升使CVP从6.1±0.5降至3.7±0.5 mmHg，并使SNA增加47±11%。出血期间SNA的增加与LBNP期间SNA百分比变化与CVP变化的相关斜率所预测的SNA增加无显著差异。这些数据表明，非低血压性出血会引起交感神经兴奋，并且在人类中对LBNP和非低血压性出血的交感反应相似。
