人类免疫缺陷病毒相关的卡波西肉瘤：流行病学与分子病理学的新进展
HIV-associated Kaposi's sarcoma: new developments in epidemiology and molecular pathology.
作者信息
Roth W K
出版信息
J Cancer Res Clin Oncol. 1991;117(3):186-91. doi: 10.1007/BF01625423.
Abstract
New epidemiological data give evidence for an unknown etiological agent of Kaposi's sarcoma (KS). Experimental support is provided by research on cultivated KS cells. These results contradict a direct involvement of HIV-1 in the pathogenesis of KS. Research on cultivated KS cells confirmed the hypothesis that KS spindle cells originate from endothelial cells and gave new insight into the pathogenesis of tumor cell growth. KS spindle cells secrete an autocrine acting growth promoting activity. Nevertheless, they seem to depend on several growth factors like PDGF and IL-6 provided by surrounding endothelial cells and macrophages, respectively. The results support the hypothesis of a tumor relying on paracrine acting factors more than on autocrine acting factors.
摘要
新的流行病学数据为卡波西肉瘤（KS）的未知病原体提供了证据。对培养的KS细胞的研究提供了实验支持。这些结果与HIV-1直接参与KS发病机制的观点相矛盾。对培养的KS细胞的研究证实了KS梭形细胞起源于内皮细胞的假说，并为肿瘤细胞生长的发病机制提供了新的见解。KS梭形细胞分泌一种自分泌作用的生长促进活性物质。然而，它们似乎分别依赖于周围内皮细胞和巨噬细胞提供的几种生长因子，如血小板衍生生长因子（PDGF）和白细胞介素-6（IL-6）。这些结果支持了肿瘤依赖旁分泌作用因子而非自分泌作用因子的假说。
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本文引用的文献
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