盐酸二苯西平对大鼠离体脑组织氧摄取、葡萄糖摄取及氧化磷酸化的影响。
Effect of dibenzepin hydrochloride on the oxygen, glucose uptake and oxidative phosphorylation of rat brain in vitro.
作者信息
Velasco-Martín A, Pérez Bejarano R, González de Zárate J L, Saiz-Martínez-Acitores I, Moreno González A
出版信息
Farmaco Sci. 1977 Sep;32(9):672-7.
PMID:20331
Abstract
Dibenzepin hydrochloride (10(-3) M) decreases the oxygen uptake of whole brain homogenates and uncouples brain mitochondrial oxidative phosphorylation. At the same concentration this drug inhibits oxygen uptake of rat brain slices when calcium is absent in the incubation or then contains an excess of potassium.
摘要
盐酸二苯氮䓬（10⁻³M）可降低全脑匀浆的氧摄取，并使脑线粒体氧化磷酸化解偶联。在相同浓度下，当孵育液中无钙或含有过量钾时，该药物会抑制大鼠脑片的氧摄取。
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