Kajiwara K, Hirozane A, Fukumoto T, Orita T, Nishizaki T, Kamiryo T, Ito H
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.
J Neuroimmunol. 1991 Jun;32(3):191-8. doi: 10.1016/0165-5728(91)90188-d.
In a healthy state, the central nervous system (CNS) is believed to be an immunologically privileged site, which does not participate in the immune reactions of the rest of the body, and in which identifiable components of the immune system are rare or non-existent. In this study, an immunohistochemical examination of the CNS of F1 hybrid rats following induction of graft-versus-host disease (GVHD) was carried out to determine whether specific immune reactions in the normal CNS could occur during a systemic immune reaction. The results revealed extensive parenchymal and vascular expression of class I and II major histocompatibility complex (MHC) encoded cell surface molecules. The strongest expressors of class I and II molecules were endothelial cells and parenchymal cells, respectively, the latter being apparently activated microglia, in the cerebrum and cerebellum of rats with GVHD. In addition, occasional scattered lymphocytes were detected in the CNS of GVHD rats without blood-brain barrier disruption. Thus, evidence was obtained for the presence of immune responses such as MHC antigen expression and lymphocyte infiltration in the CNS during a strong systemic immune response such as GVHD, microglia and endothelial cells apparently playing an important role.
在健康状态下，中枢神经系统（CNS）被认为是一个免疫特权部位，它不参与身体其他部位的免疫反应，且免疫系统的可识别成分在其中很少见或不存在。在本研究中，对诱导移植物抗宿主病（GVHD）后的F1杂种大鼠的中枢神经系统进行了免疫组织化学检查，以确定在全身免疫反应期间正常中枢神经系统中是否会发生特异性免疫反应。结果显示，I类和II类主要组织相容性复合体（MHC）编码的细胞表面分子在实质和血管中广泛表达。I类和II类分子的最强表达者分别是内皮细胞和实质细胞，后者在患有GVHD的大鼠的大脑和小脑中显然是活化的小胶质细胞。此外，在没有血脑屏障破坏的GVHD大鼠的中枢神经系统中偶尔检测到散在的淋巴细胞。因此，获得了证据表明在诸如GVHD这样强烈的全身免疫反应期间，中枢神经系统中存在免疫反应，如MHC抗原表达和淋巴细胞浸润，小胶质细胞和内皮细胞显然发挥了重要作用。
