Department of Psychology, University of Washington, Seattle, 98195, USA.
Alcohol Clin Exp Res. 2010 May;34(5):925-7. doi: 10.1111/j.1530-0277.2010.01165.x. Epub 2010 Mar 10.
Effects of alcohol vary depending on blood alcohol level and limb. Some researchers use standard absorption periods (SAPs) to determine when postdrinking experimental protocols should begin. Others use an idiographically determined absorption period (IDAP) based on criterion breath alcohol concentration (BrAC). We investigated and compared the characteristics of each method.
Sixty-eight social drinkers (47% women) consumed a bolus dose of alcohol intended to raise BrAC to 0.08%. BrACs were recorded every 3 minutes until beginning to descend. Minutes to reach criterion BrAC (0.06%) and between-subjects postdrinking BrAC variability were analyzed.
Mean time to reach 0.06% BrAC was 22.9 +/- 14.6 minutes. Standard deviations in BrAC were 4 times greater using SAPs compared to IDAPs. Ten percent of participants' BrAC readings were on the descending limb 30 minutes postdrinking, and 25% were descending at 45 minutes postdrinking.
IDAPs result in less BrAC variability and may reduce experimental noise relative to SAPs. Experimental control in future alcohol administration studies may be enhanced by the use of IDAPs instead of SAPs.
酒精的影响取决于血液酒精水平和肢体。一些研究人员使用标准吸收期（SAP）来确定应该何时开始饮酒后的实验方案。其他人则根据临界呼气酒精浓度（BrAC）使用个体确定的吸收期（IDAP）。我们研究并比较了每种方法的特点。
68 名社交饮酒者（47%为女性）摄入了一剂旨在将 BrAC 提高到 0.08%的酒精。在开始下降之前，每 3 分钟记录一次 BrAC。分析达到临界 BrAC（0.06%）的时间和个体间饮酒后 BrAC 变异性。
达到 0.06% BrAC 的平均时间为 22.9 +/- 14.6 分钟。与 IDAP 相比，SAP 中 BrAC 的标准偏差高 4 倍。10%的参与者在饮酒后 30 分钟时 BrAC 读数处于下降阶段，25%的参与者在饮酒后 45 分钟时 BrAC 读数处于下降阶段。
IDAP 导致的 BrAC 变异性较小，与 SAP 相比可能减少实验噪声。通过使用 IDAP 而不是 SAP，未来的酒精给药研究中的实验控制可能会得到增强。
