Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France.
Epilepsia. 2010 Feb;51 Suppl 1(suppl 5):92-3. doi: 10.1111/j.1528-1167.2009.02459.x.
Neural stem cells (NSCs) are one of the candidates for grafting in the realm of cell-based therapy for temporal lobe epilepsy (TLE). Because NSCs can produce neurons synthesizing the inhibitory neurotransmitter GABA and cells secreting multiple neurotrophic factors, NSC grafting therapy has promise for restraining seizures and easing cognitive dysfunction in TLE. For an expanded treatment of this topic see (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press. Available on NCBI Bookshelf.
神经干细胞(NSCs)是细胞治疗颞叶癫痫(TLE)领域中移植的候选细胞之一。由于 NSCs 可以产生合成抑制性神经递质 GABA 的神经元和分泌多种神经营养因子的细胞,因此 NSC 移植治疗有望抑制 TLE 中的癫痫发作和缓解认知功能障碍。有关此主题的更广泛治疗,请参见由牛津大学出版社出版的(Noebels JL、Avoli M、Rogawski MA、Olsen RW、Delgado-Escueta AV 编)。可在 NCBI Bookshelf 上获得。