混合性生殖细胞肿瘤皮肤转移：病例报告及文献复习。
Mixed germ cell tumor metastatic to the skin: case report and literature review.
机构信息
Division of Uro-oncology, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
出版信息
World J Surg Oncol. 2010 Mar 23;8:21. doi: 10.1186/1477-7819-8-21.
BACKGROUND
Testicular cancer is the most common cancer for males aged 15 to approximately 35 years old. The initial presentation is typically an asymptomatic enlarged testicle. The retroperitoneum is the most common metastatic area. Other metastatic sites include the lung, liver, brain, adrenal glands, gastrointestinal tract and spleen. Skin metastasis is a rare event and frequently associated with poor prognosis.
CASE PRESENTATION
A 19-year old male was diagnosed testicular mixed germ cell tumor with initial presentation of cutaneous metastasis at scalp and upper abdomen. After radical orchiectomy and four courses of cisplatin-based chemotherapy, the scalp and upper abdominal lesions regressed completely. The size of lung metastases remained unchanged.
CONCLUSIONS
For advanced stage testicular cancer, cisplatin-based chemotherapy is still effective to achieve partial response.
背景
睾丸癌是 15 岁至 35 岁男性中最常见的癌症。最初的表现通常是无症状的单侧睾丸肿大。腹膜后是最常见的转移部位。其他转移部位包括肺、肝、脑、肾上腺、胃肠道和脾脏。皮肤转移是一种罕见的事件，通常与预后不良有关。
病例介绍
一名 19 岁男性被诊断为睾丸混合生殖细胞瘤，最初表现为头皮和上腹部皮肤转移。行根治性睾丸切除术和 4 个疗程顺铂为基础的化疗后，头皮和上腹部病变完全消退。肺部转移灶大小无变化。
结论
对于晚期睾丸癌，顺铂为基础的化疗仍然有效，可以达到部分缓解。
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