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植入式除颤器的益处被猝死率高估,而用心律失常总死亡率能更好地体现。

Benefits of implantable defibrillators are overestimated by sudden death rates and better represented by the total arrhythmic death rate.

作者信息

Kim S G, Fisher J D, Furman S, Gross J, Zilo P, Roth J A, Ferrick K J, Brodman R

机构信息

Department of Medicine, Montefiore Medical Center, Bronx, New York 10467.

出版信息

J Am Coll Cardiol. 1991 Jun;17(7):1587-92. doi: 10.1016/0735-1097(91)90652-p.

Abstract

Benefits of the implantable defibrillator on survival were studied in 56 consecutive patients (concomitant coronary bypass or arrythmia surgery in 15) during an 8 year period between 1982 and 1990. During a follow-up period of 29 +/- 25 months, six patients had a sudden death and eight patients had a nonsudden cardiac death. Nonsudden cardiac deaths included three surgical deaths (death within 30 days after the surgery; two in patients without and one in a patient with concomitant cardiac surgery), one arrhythmia-related nonsudden death (death within 24 h after an arrhythmic event despite initial termination of the arrhythmia by the implantable defibrillators) and four nonarrhythmic cardiac deaths. The actuarial survival rate free of events at 1, 2 and 3 years was 96%, 96% and 92%, respectively, for sudden death, 91%, 91% and 87% for sudden death and surgical mortality and 89%, 89% and 85% for total arrhythmic death (sudden death, surgical mortality and arrhythmia-related nonsudden death). Thus, in patients treated with an implantable defibrillator, 1) the rate of sudden death is low (8% at 3 years); 2) 50% of nonsudden cardiac deaths are causally related to arrhythmia (surgical mortality or arrhythmia-related nonsudden death); 3) the total arrhythmic death rate is substantially higher than the sudden death rate; and 4) benefits of an implantable defibrillator are overestimated by reported sudden death and nonsudden cardiac death rates. The benefits may be better represented by the total arrhythmic death and nonarrhythmic cardiac death rates.

摘要

1982年至1990年的8年期间,对56例连续患者(其中15例同时进行冠状动脉搭桥或心律失常手术)植入式除颤器对生存率的益处进行了研究。在29±25个月的随访期内,6例患者猝死,8例患者非猝死性心脏死亡。非猝死性心脏死亡包括3例手术死亡(术后30天内死亡;2例无心脏手术患者,1例同时进行心脏手术患者),1例心律失常相关非猝死(心律失常事件后24小时内死亡,尽管植入式除颤器最初终止了心律失常)和4例非心律失常性心脏死亡。1年、2年和3年无事件的精算生存率,猝死分别为96%、96%和92%,猝死和手术死亡率分别为91%、91%和87%,总心律失常死亡率(猝死、手术死亡率和心律失常相关非猝死)分别为89%、89%和85%。因此,在接受植入式除颤器治疗的患者中,1)猝死率较低(3年时为8%);2)50%的非猝死性心脏死亡与心律失常有因果关系(手术死亡率或心律失常相关非猝死);3)总心律失常死亡率远高于猝死率;4)报告的猝死和非猝死性心脏死亡率高估了植入式除颤器的益处。总心律失常死亡率和非心律失常性心脏死亡率可能能更好地体现其益处。

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