Hum Exp Toxicol. 2010 Apr;29(4):283-5. doi: 10.1177/0960327110363966.
Change comes as a surprise because things do not happen in a straight line. Concepts often evolve haphazardly, reacting to specific events. Assumptions are made but are not challenged, sometimes for political or social expedience. It has long been recognized that the dose makes the poison. Concepts of the relationship evolved from both events and the availability of exploratory tools. There are consequences to risk aversion. The general concept of hormesis is perhaps not unexpected. The acceptance of multiphasic dose-responses has the potential to unleash additional and productive insights into this relationship. The activities of BELLE and its Newsletter provide an excellent example of what can be achieved when dogmas are challenged by the accrual of information that has not been previously examined to see whether additional insights are possible. A forthcoming challenge will be the critical examination of all the inputs and assumptions that will be used in the increasing sophistication of biological modeling.
变革往往出人意料，因为事物的发展并非直线前进。概念的演变常常是偶然的，对特定事件做出反应。人们做出假设，但不会提出质疑，有时是出于政治或社会利益的考虑。人们早就认识到，剂量决定毒性。这种关系的概念源自事件的发生和探索性工具的可用性。回避风险会产生后果。或许，毒物兴奋效应的普遍概念并不出人意料。接受多相剂量反应有潜力为这种关系带来更多富有成效的新认识。BELLE 及其通讯的活动为当教条受到尚未经过检验的信息积累的挑战时可以取得的成果提供了一个极好的范例，这些信息有可能带来新的认识。即将面临的挑战将是对所有投入和假设进行严格审查，这些投入和假设将用于日益复杂的生物建模。
