Calabrese Edward J
Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Crit Rev Toxicol. 2008;38(5):453-62. doi: 10.1080/10408440802004007.
This article traces the historical foundations of the Yerkes-Dodson Law from its experimental foundations in the first decade of the 20th century, to its recognition as a generalizable phenomenon in multiple species including humans and to more current attempts to understand its molecular basis within the framework of stress-related biological processes. Within this context, the biological and dose-response characteristics of the Yerkes-Dodson Law are evaluated and compared to the hormesis dose-response model. Based on this evaluation, which includes study design analysis, statistical models of multiple factor/chemical interaction, and a comparative assessment of the quantitative features of these respective dose-response relationships and their molecular foundations, the Yerkes-Dodson Law is shown to represent a special case of the general concept of hormesis illustrating the interaction of two independent study variables, which has typically been observed to be an additive response, although not theoretically restricted to one. The conceptual integration of the Yerkes-Dodson Law within the hormetic dose response framework adds further support for the generalization of the hormesis concept.
本文追溯了耶基斯-多德森定律的历史基础，从20世纪头十年的实验基础，到其被认可为包括人类在内的多种物种中的可推广现象，再到当前在应激相关生物过程框架内理解其分子基础的尝试。在此背景下，对耶基斯-多德森定律的生物学和剂量反应特征进行了评估，并与兴奋效应剂量反应模型进行了比较。基于这一评估，包括研究设计分析、多因素/化学相互作用的统计模型，以及对这些各自剂量反应关系及其分子基础的定量特征的比较评估，耶基斯-多德森定律被证明代表了兴奋效应一般概念的一个特例，说明了两个独立研究变量的相互作用，通常观察到这是一种加性反应，尽管理论上并不局限于此。将耶基斯-多德森定律概念性地整合到兴奋效应剂量反应框架中，进一步支持了兴奋效应概念的推广。
