白细胞介素 1β（IL1B）基因多态性与德国胃癌的发生无关。
Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany.
机构信息
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
出版信息
Anticancer Res. 2010 Feb;30(2):505-11.
BACKGROUND
Polymorphisms of interleukin-1 beta gene (IL1B-511C>T) are considered as risk factor for gastric carcinogenesis, but conflicting data have been reported recently.
PATIENTS AND METHODS
The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls.
RESULTS
While identified frequencies of genotypes, haplotypes and haplotype pairs corresponded to those of other studies in Caucasians, none were significantly associated with the presence of gastric cancer or premalignant alterations.
CONCLUSION
None of the four major polymorphisms is individually or in its haplotype configuration linked to the development of GC in this Caucasian population in Germany.
背景
白细胞介素-1β基因（IL1B-511C>T）的多态性被认为是胃癌发生的危险因素，但最近有相互矛盾的报道。
患者和方法
分别分析了 116 例胃癌患者和 142 例“高危胃炎”患者以及 94 例健康对照者中四个主要 IL1B 变体（IL1B-3737C>T、-1464G>C、-511C>T、-31T>C）的分布情况。
结果
虽然基因型、单倍型和单倍型对的鉴定频率与白种人中的其他研究一致，但与胃癌或癌前病变的存在均无显著相关性。
结论
在德国的这个白种人群中，四个主要多态性中的任何一个都不能单独或与其单倍型结构相关联，从而导致 GC 的发展。
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