吸烟与慢性胰腺炎独立相关。

Cigarette smoking is independently associated with chronic pancreatitis.

机构信息

Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

出版信息

Pancreatology. 2010;10(1):54-9. doi: 10.1159/000225927. Epub 2010 Mar 20.

DOI:10.1159/000225927

PMID:20332662

Abstract

BACKGROUND AND AIMS

It is not completely understood whether smoking contributes to chronic pancreatitis (CP). Past studies have included mostly patients with alcohol-related and severe CP. Our aim was to assess the relationship of smoking and CP adjusting for alcohol and other clinical risk factors.

METHODS

A cross-sectional study was performed of patients referred to the pancreatic disease clinic in the past 2 years with abdominal pain and suspected CP. Patients were questioned on their smoking and alcohol habits. Patients underwent an etiological workup and diagnostic evaluation for early and late CP comprised of computed tomography scan and combined endoscopic ultrasound and secretin endoscopic pancreatic function test if indicated. Logistic regression was used to determine the association of current smoking with CP adjusting for other risk factors.

RESULTS

The adjusted odds ratio (OR) for current smoking was 1.99 (95% CI 1.01, 3.91). Other significant predictors included consumption of > or =10 alcohol drinks/week, advancing age, history of acute pancreatitis, and the presence of another etiological factor. Smoking was also independently associated with exocrine insufficiency (OR 2.00, 95% CI 1.07, 3.75) and calcifications (OR 2.68, 95% CI 1.03, 6.94).

CONCLUSION

Active cigarette smoking is associated with CP adjusting for alcohol and other risk factors. and IAP.

摘要

背景与目的

目前尚不完全清楚吸烟是否会导致慢性胰腺炎（CP）。既往的研究大多包括与酒精相关的和严重的 CP 患者。我们的目的是评估在调整酒精和其他临床危险因素后，吸烟与 CP 的关系。

方法

对过去 2 年因腹痛和疑似 CP 而到胰腺疾病诊所就诊的患者进行了一项横断面研究。询问了患者的吸烟和饮酒习惯。对患者进行病因学检查和早期和晚期 CP 的诊断评估，包括 CT 扫描以及在有指征的情况下进行联合内镜超声和促胰液素内镜胰腺功能检查。使用逻辑回归来确定当前吸烟与 CP 之间的关联，同时调整其他危险因素。

结果

当前吸烟的调整后比值比（OR）为 1.99（95%可信区间 1.01，3.91）。其他显著的预测因素包括每周饮酒≥10 杯、年龄增长、急性胰腺炎病史和存在其他病因因素。吸烟也与外分泌功能不全（OR 2.00，95%可信区间 1.07，3.75）和钙化（OR 2.68，95%可信区间 1.03，6.94）独立相关。