Bonner R, Nossal R
Appl Opt. 1981 Jun 15;20(12):2097-107. doi: 10.1364/AO.20.002097.
A theory is developed which relates quasi-elastic light scattering measurements to blood flow in tissue micro-vasculature. We assume that the tissue matrix surrounding the blood cells is a strong diffuser of light and that moving erythrocytes, therefore, are illuminated by a spatially distributed source. Because the surrounding tissue is considered to be stationary, Doppler shifts in the frequency of the scattered light arise only from photon interactions with the moving blood cells. The theory implies that the time decay of the photon autocorrelation function scales proportionally with cell size and inversely with mean translational speed. Analysis of multiple interactions of photons with moving cells indicates the manner in which spectral measurements additionally are sensitive to changes in blood volume. Predictions are verified by measurements of particle flow in model tissues.
本文提出了一种理论，该理论将准弹性光散射测量与组织微血管中的血流联系起来。我们假设血细胞周围的组织基质是光的强散射体，因此，移动的红细胞由空间分布的光源照亮。由于周围组织被认为是静止的，散射光频率的多普勒频移仅源于光子与移动血细胞的相互作用。该理论表明，光子自相关函数的时间衰减与细胞大小成正比，与平均平移速度成反比。对光子与移动细胞的多次相互作用的分析表明了光谱测量对血容量变化额外敏感的方式。通过对模型组织中颗粒流的测量验证了预测结果。
