Gu Jiaping, Zheng James Q
Departments of Cell Biology and Neurology, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322.
Open Neurosci J. 2009 Dec 25;3:128-133. doi: 10.2174/1874082000903020128.
Recent studies indicate that microtubules (MTs) may play an important role in spine development and dynamics. Several imaging studies have now documented the exploration of dendritic spines by dynamic MTs in an activity-dependent manner. Furthermore, it was found that alterations of MT dynamics by pharmacological and molecular approaches exert profound influence on the development and plasticity of spines associated with neuronal activity. It is reasonable to speculate that dynamic MTs may be responsible for targeted delivery of specific cargos to a selected number of spines and/or for interacting with the actin cytoskeleton to generate the structural changes of spines associated with synaptic modifications.
近期研究表明，微管（MTs）可能在脊柱发育和动态变化中发挥重要作用。现在有几项成像研究记录了动态微管以活动依赖的方式对树突棘的探索。此外，研究发现，通过药理学和分子学方法改变微管动力学，会对与神经元活动相关的脊柱发育和可塑性产生深远影响。据推测，动态微管可能负责将特定货物靶向递送至选定数量的棘突，和/或与肌动蛋白细胞骨架相互作用，以产生与突触修饰相关的棘突结构变化。
