分枝杆菌诱导的中枢神经系统自身免疫抑制。
Mycobacteria-induced suppression of autoimmunity in the central nervous system.
机构信息
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA.
出版信息
J Neuroimmune Pharmacol. 2010 Jun;5(2):210-9. doi: 10.1007/s11481-010-9199-6. Epub 2010 Mar 24.
Abstract
Mycobacterial suppression of central nervous system (CNS) autoimmunity has been demonstrated in various experimental models, epidemiological studies, and clinical trials. Recent studies have led to an increased understanding of the cellular and molecular interactions involved in the pathogenesis of autoimmune diseases and of mycobacterial immunity. Here, we review some of the mechanisms by which mycobacterial infection might modulate the clinical course of CNS autoimmunity. A more complete understanding of these mechanisms may lead to the development of novel immunotherapeutic tools for treating autoimmune diseases.
摘要
分枝杆菌对中枢神经系统（CNS）自身免疫的抑制作用已在各种实验模型、流行病学研究和临床试验中得到证实。最近的研究加深了人们对参与自身免疫性疾病发病机制和分枝杆菌免疫的细胞和分子相互作用的理解。在这里，我们回顾了分枝杆菌感染可能调节 CNS 自身免疫临床病程的一些机制。对这些机制的更全面了解可能会导致开发出治疗自身免疫性疾病的新型免疫治疗工具。
相似文献
1
Mycobacteria-induced suppression of autoimmunity in the central nervous system.分枝杆菌诱导的中枢神经系统自身免疫抑制。
J Neuroimmune Pharmacol. 2010 Jun;5(2):210-9. doi: 10.1007/s11481-010-9199-6. Epub 2010 Mar 24.
2
Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.目前对 Th1 和 Th17 细胞在实验性自身免疫性脑脊髓炎中的作用的看法。
J Neuroimmune Pharmacol. 2010 Jun;5(2):189-97. doi: 10.1007/s11481-009-9188-9. Epub 2010 Jan 27.
3
Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.蠕虫和分枝杆菌感染对中枢神经系统自身免疫的免疫调节作用。
Immunol Lett. 2002 Jun 3;82(1-2):101-10. doi: 10.1016/s0165-2478(02)00025-1.
4
Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.中枢神经系统中的牛分枝杆菌卡介苗感染以不依赖于γ干扰素的方式抑制实验性自身免疫性脑脊髓炎和Th17反应。
J Immunol. 2008 Nov 1;181(9):6201-12. doi: 10.4049/jimmunol.181.9.6201.
5
Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination.Th17细胞在中枢神经系统炎性脱髓鞘发病机制中的作用。
J Neurol Sci. 2013 Oct 15;333(1-2):76-87. doi: 10.1016/j.jns.2013.03.002. Epub 2013 Apr 8.
6
Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm.自身免疫性脑脊髓炎的 CD4/T(H)1 以外的新观念。
Ann Anat. 2010 Aug 20;192(4):179-93. doi: 10.1016/j.aanat.2010.06.006. Epub 2010 Jul 15.
7
Astrocyte-induced regulatory T cells mitigate CNS autoimmunity.星形胶质细胞诱导的调节性T细胞减轻中枢神经系统自身免疫。
Glia. 2004 Aug 1;47(2):168-79. doi: 10.1002/glia.20046.
8
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.多发性硬化症和实验性自身免疫性脑脊髓炎中的 T 细胞。
Clin Exp Immunol. 2010 Oct;162(1):1-11. doi: 10.1111/j.1365-2249.2010.04143.x.
9
Astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis: Star-shaped cells illuminating the darkness of CNS autoimmunity.多发性硬化症和实验性自身免疫性脑脊髓炎中的星形胶质细胞：照亮中枢神经系统自身免疫黑暗的星形细胞。
Brain Behav Immun. 2019 Aug;80:10-24. doi: 10.1016/j.bbi.2019.05.029. Epub 2019 May 21.
10
The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal.多发性硬化症的CD4-Th1模型：一项重要的重新评估
Trends Immunol. 2004 Mar;25(3):132-7. doi: 10.1016/j.it.2004.01.007.
引用本文的文献
1
Mycobacterium celatum encephalitis in an immunocompromised host mimicking autoimmune striatal encephalitis: the first case report.免疫功能低下宿主中模仿自身免疫性纹状体脑炎的塞拉托分枝杆菌脑炎：首例病例报告
BMC Infect Dis. 2025 Mar 6;25(1):321. doi: 10.1186/s12879-025-10602-5.
2
Systemic Infection Redirects Leukocyte Infiltration to the Kidneys Attenuating Encephalomyelitis.全身性感染将白细胞浸润重定向至肾脏，减轻脑脊髓炎。
J Fungi (Basel). 2021 Sep 14;7(9):757. doi: 10.3390/jof7090757.
3
Leukoencephalopathy resolution after atypical mycobacterial treatment: a case report.非典型分枝杆菌治疗后白质脑病的缓解：一例报告
BMC Neurol. 2015 Sep 2;15:159. doi: 10.1186/s12883-015-0415-0.
4
Functional profiling of the gut microbiome in disease-associated inflammation.疾病相关炎症中肠道微生物群的功能分析
Genome Med. 2013 Jul 31;5(7):65. doi: 10.1186/gm469. eCollection 2013.
5
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination.IL-17 诱导的 Act1 介导的信号转导对于铜诱导脱髓鞘至关重要。
J Neurosci. 2012 Jun 13;32(24):8284-92. doi: 10.1523/JNEUROSCI.0841-12.2012.
6
Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system.实验性自身免疫性脑脊髓炎的辅助免疫治疗：表达 CXCL10 和 CXCL16 的未成熟髓样细胞吸引 CXCR3+CXCR6+和髓鞘特异性 T 细胞到引流淋巴结而不是中枢神经系统。
J Immunol. 2012 Mar 1;188(5):2093-101. doi: 10.4049/jimmunol.1101118. Epub 2012 Jan 27.
7
Neuroimmune pharmacological control of EAE.实验性自身免疫性脑脊髓炎的神经免疫药理学控制
J Neuroimmune Pharmacol. 2010 Jun;5(2):165-7. doi: 10.1007/s11481-010-9219-6. Epub 2010 Apr 23.
本文引用的文献
1
Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.Toll样受体2和聚（ADP-核糖）聚合酶1在进行性实验性自身免疫性脑脊髓炎中促进中枢神经系统神经炎症。
Nat Immunol. 2009 Sep;10(9):958-64. doi: 10.1038/ni.1775. Epub 2009 Aug 16.
2
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.白细胞介素23受体对于体内产生白细胞介素17的效应性辅助性T细胞的终末分化至关重要。
Nat Immunol. 2009 Mar;10(3):314-24. doi: 10.1038/ni.1698. Epub 2009 Feb 1.
3
Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.中枢神经系统中的牛分枝杆菌卡介苗感染以不依赖于γ干扰素的方式抑制实验性自身免疫性脑脊髓炎和Th17反应。
J Immunol. 2008 Nov 1;181(9):6201-12. doi: 10.4049/jimmunol.181.9.6201.
4
Regulatory T cells and immune tolerance.调节性T细胞与免疫耐受。
Cell. 2008 May 30;133(5):775-87. doi: 10.1016/j.cell.2008.05.009.
5
Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs.分枝杆菌与天然免疫受体的相互作用：Toll样受体、C型凝集素和NOD样受体。
Curr Opin Infect Dis. 2008 Jun;21(3):279-86. doi: 10.1097/QCO.0b013e3282f88b5d.
6
gammadelta T cells: an important source of IL-17.γδ T细胞：白细胞介素-17的重要来源。
Curr Opin Immunol. 2008 Jun;20(3):353-7. doi: 10.1016/j.coi.2008.03.006. Epub 2008 Apr 23.
7
TLR-activated B cells suppress T cell-mediated autoimmunity.Toll样受体激活的B细胞可抑制T细胞介导的自身免疫。
J Immunol. 2008 Apr 1;180(7):4763-73. doi: 10.4049/jimmunol.180.7.4763.
8
The 'short' history of regulatory B cells.调节性B细胞的“简史”。
Trends Immunol. 2008 Jan;29(1):34-40. doi: 10.1016/j.it.2007.10.004. Epub 2007 Dec 3.
9
10
Increased frequency of CD4(+)CD25(high) Treg cells inhibit BCG-specific induction of IFN-gamma by CD4(+) T cells from TB patients.CD4(+)CD25(high)调节性T细胞频率增加会抑制结核病患者CD4(+)T细胞对卡介苗特异性的γ干扰素诱导。
Tuberculosis (Edinb). 2007 Nov;87(6):526-34. doi: 10.1016/j.tube.2007.07.004. Epub 2007 Sep 11.
Zotero 插件