Jamieson W R E, Forgie W R, Hayden R I, Langlois Y, Ling H, Stanford E A, Roberts K A, Dolman W B
Division of Cardiovascular Surgery, University of British Columbia, Vancouver, Canada.
Thorac Cardiovasc Surg. 2010 Mar;58(2):69-75. doi: 10.1055/s-0029-1240626. Epub 2010 Mar 23.
Documentation of the hemodynamics of the Mitroflow aortic pericardial bioprosthesis has been incomplete. The aim of the study was to provide reference effective orifice areas for the implant calculation of effective orifice area indexes to avoid prosthesis-patient mismatch.
Echocardiograms were evaluated in 55 patients (39 females, 16 males), mean age 77.0 +/- 6.9 years (range 51-90 years). The mean time of the studies was 11.0 months. The prosthesis sizes and numbers evaluated were 19 mm (n = 13), 21 mm (n = 19), 23 mm (n = 13) and 25 mm (n = 10).
Peak aortic velocities averaged from 2.2 to 2.7 m/sec, mean gradients from 10.6 to 15.1 mmHg, peak gradients from 20.7 to 29.7 mmHg, and effective orifice area (EOA) from 1.4 to 1.8 cm (2). When accounting for the subaortic velocity, mean gradients averaged from 7.5 to 10.0 mmHg, and peak gradients averaged 15.1 to 23.5 mmHg. The effective orifice area indexes ranged from 0.8 to 1.0 cm (2)/m (2). The mean postoperative left ventricular mass index was 101.6 gm/m (2).
The IN VIVO effective orifice areas by valve size of the Mitroflow aortic pericardial bioprosthesis provide the opportunity of avoiding obstructive characteristics for all valve sizes, including optimizing the management of the small aortic annulus.
Mitroflow主动脉心包生物瓣膜血流动力学的记录并不完整。本研究的目的是为植入有效瓣口面积指数计算提供参考有效瓣口面积，以避免人工瓣膜-患者不匹配。
对55例患者（39例女性，16例男性）进行超声心动图评估，平均年龄77.0±6.9岁（范围51-90岁）。研究的平均时间为11.0个月。评估的人工瓣膜尺寸和数量分别为19mm（n=13）、21mm（n=19）、23mm（n=13）和25mm（n=10）。
主动脉峰值速度平均为2.2至2.7m/秒，平均压差为10.6至15.1mmHg，峰值压差为20.7至29.7mmHg，有效瓣口面积（EOA）为1.4至1.8cm²。考虑主动脉下速度时，平均压差平均为7.5至10.0mmHg，峰值压差平均为15.1至23.5mmHg。有效瓣口面积指数范围为0.8至1.0cm²/m²。术后左心室质量指数平均为101.6gm/m²。
Mitroflow主动脉心包生物瓣膜按瓣膜尺寸的体内有效瓣口面积为所有瓣膜尺寸避免梗阻特征提供了机会，包括优化小主动脉瓣环的管理。
