Kume A, Takahashi A, Hashizume Y, Asai J
Department of Neurology, Nagoya University School of Medicine, Japan.
J Neurol Sci. 1991 Feb;101(2):178-86. doi: 10.1016/0022-510x(91)90043-7.
We examined pathologically 21 cases of multiple system atrophy (MSA). Density of Purkinje cell in 16 cases and of olivary nucleus cell in 20 cases was quantitatively measured, and their distribution as well as degree were studied. Contrary to the findings of previous reports, Purkinje cell loss was more pronounced in the vermis than in the hemispheres. Olivary nucleus cell loss was more outstanding in the accessory nucleus than in the inferior nucleus. A topographical characteristic of cell degeneration exists between the Purkinje layer and the olivary nucleus. Significant sparing of the nodulus apparently related to that of the vestibular system was found. While the common distribution of cell loss was seen, its degree varied considerably case by case. The degree was related to both duration of illness and, to some extent, clinical subtypes of MSA.
我们对21例多系统萎缩（MSA）患者进行了病理检查。定量测量了16例患者的浦肯野细胞密度和20例患者的橄榄核细胞密度，并研究了它们的分布及程度。与既往报道结果相反，蚓部浦肯野细胞丢失比半球更明显。副橄榄核细胞丢失比下橄榄核更显著。浦肯野层和橄榄核之间存在细胞变性的地形学特征。发现小结明显保留，这显然与前庭系统的保留有关。虽然观察到细胞丢失的常见分布，但其程度在不同病例中差异很大。该程度与病程以及在一定程度上与MSA的临床亚型均有关。
