Kulczycki J
Department of Neurology, Institute of Psychiatry and Neurology, Warszawa.
Folia Neuropathol. 1997;35(4):209-13.
Multiple system atrophy (MSA) is a degenerative disease of the central nervous system with three components, usually variously expressed: nigrostriatal degeneration (NSD), olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome of autonomic system dysfunction (SDS). The clinical progression of MSA leads to death in a shorter time than in any of the components occurring separately. A common, and according to some authors, pathognomonic neuropathological finding in MSA cases is the presence of argyrophilic inclusions in the cytoplasm of glial cells, mainly oligodendrocytes, in the structures of the encephalon with most pronounced atrophic changes.
多系统萎缩（MSA）是一种中枢神经系统退行性疾病，由三个部分组成，通常表现各异：黑质纹状体变性（NSD）、橄榄脑桥小脑萎缩（OPCA）和自主神经系统功能障碍的夏伊-德雷格综合征（SDS）。与单独出现的任何一个部分相比，MSA的临床进展导致死亡的时间更短。MSA病例中一个常见的、一些作者认为具有病理诊断意义的神经病理学发现是，在脑结构中，主要是少突胶质细胞的胶质细胞胞质内存在嗜银包涵体，萎缩变化最为明显。
