Makerere University, Institute of Environment and Natural Resources, Molecular Biology Laboratory, Kampala, Uganda.
Epidemiol Infect. 2011 Feb;139(2):189-96. doi: 10.1017/S0950268810000580. Epub 2010 Mar 25.
Most viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (π = 0·0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.
大多数病毒通过复杂的进化过程得以维持，这使它们能够存活，但也使控制病毒的努力变得复杂。本文研究了肯尼亚口蹄疫（FMD）血清型 C 病毒分离株的进化模式，肯尼亚是世界上少数几个血清型 C 地方性流行且疑似仍存在的地方之一。对 1967 年至 2004 年间采集的 8 个分离株的衣壳蛋白 VP1 编码核苷酸序列进行了分析，以研究序列差异和进化模式。在近 40 年的时间里，这些分离株的核苷酸多样性非常低（π=0.0025），变化很小（只有 5 个分离位点和 3 个氨基酸变化）。我们将这些结果解释为疫苗株再次引入田间的迹象。这些结果对口蹄疫 C 型病毒的维持以及肯尼亚使用疫苗接种作为控制措施的影响进行了讨论。
