Chillarón Juan J, Flores-Le-Roux Juana A, Goday Alberto, Benaiges David, Carrera María J, Puig Jaume, Cano-Pérez Juan F, Pedro-Botet Juan
Servicio de Endocrinología y Nutrición. Hospital del Mar. Barcelona. España. Departamento de Medicina. Universidad Autónoma de Barcelona. Barcelona. España.
Rev Esp Cardiol. 2010 Apr;63(4):423-9.
Numerous clinical and epidemiological studies have highlighted the fact that metabolic syndrome is an important precursor of cardiovascular disease. Metabolic syndrome is generally associated with type-2 diabetes, and few data exist on its occurrence in type-1 diabetes. The aims of this study were to determine the prevalence of metabolic syndrome in patients with type-1 diabetes and to identify associated factors.
This cross-sectional study included consecutive patients aged over 18 years with autoimmune type-1 diabetes of more than 6 months' duration who were treated during 2008 at the Outpatient Endocrinology Clinic of the Hospital del Mar, Barcelona, Spain. The presence of metabolic syndrome was determined using the modified criteria proposed by the National Cholesterol Education Program-Adult Treatment Panel III.
Overall, 31.9% (95% confidence interval [CI], 22.3%-41.5%) of patients with type-1 diabetes had metabolic syndrome. The following factors were significantly and independently associated with the presence of metabolic syndrome in patients with type-1 diabetes: age (odds ratio [OR]=1.09; 95% CI, 1.029-1.154), body mass index (OR=1.389; 95% CI, 1.134-1.702) and glycosylated hemoglobin level (OR=1.745; 95% CI, 1.081-2.815). In addition, there was a direct relationship between the number of components of metabolic syndrome present and prevalence of microangiopathy, which reached 100% in patients who satisfied all diagnostic criteria.
Metabolic syndrome was common in patients with type-1 diabetes and was associated with microvascular complications.
众多临床和流行病学研究都强调了代谢综合征是心血管疾病的重要先兆这一事实。代谢综合征通常与2型糖尿病相关，而关于其在1型糖尿病中的发生情况的数据较少。本研究的目的是确定1型糖尿病患者中代谢综合征的患病率，并识别相关因素。
这项横断面研究纳入了2008年在西班牙巴塞罗那市海洋医院门诊内分泌科接受治疗的、年龄超过18岁、患有病程超过6个月的自身免疫性1型糖尿病的连续患者。采用美国国家胆固醇教育计划成人治疗专家组第三次报告提出的修改标准来确定代谢综合征的存在。
总体而言，31.9%（95%置信区间[CI]，22.3%-41.5%）的1型糖尿病患者患有代谢综合征。以下因素与1型糖尿病患者代谢综合征的存在显著且独立相关：年龄（优势比[OR]=1.09；95%CI，1.029-1.154）、体重指数（OR=1.389；95%CI，1.134-1.702）和糖化血红蛋白水平（OR=1.745；95%CI，1.081-2.815）。此外，代谢综合征存在的组分数量与微血管病变的患病率之间存在直接关系，在满足所有诊断标准的患者中微血管病变患病率达到100%。
代谢综合征在1型糖尿病患者中很常见，并且与微血管并发症相关。
