Ben Salah Dhoha, Elleuch Mouna, Soomauroo Siddiqa, Boujelben Khouloud, Turki Imen, Hadjkacem Faten, Charfi Nadia, Mnif Fatma, Mnif Mouna, Abid Mohamed, Rekik Nabila
Endocrinology-Diabetology Department, Hédi Chaker Hospital, Sfax, Tunisia.
Research Laboratory"Quality of Care and Management of Maternal Health Services" LR12ES03,Doctoral Commission 'Health Sciences', Faculty of Medicine of Sousse, University of Sousse, 4002 Sousse, Tunisia.
Tunis Med. 2024 Dec 5;102(12):1031-1034. doi: 10.62438/tunismed.v102i12.4916.
Metabolic syndrome (MS) is responsible for the increased cardiovascular risk in patients with type 2 diabetes. Few studies have focused on MS in type 1 diabetes mellitus (T1DM).
To describe the clinical, biochemical and therapeutic characteristics of T1DM patients affected by MS.
A retrospective study was carried out. It included 36 patients, suffering from T1DM and MS, hospitalized in the Endocrinology-Diabetology Department of the Hédi Chaker University Hospital of Sfax-Tunisia, from 1997 to 2020. MS was defined according to the NCEP-ATP III criteria.
The mean age of the patients was 53 years. The mean duration of diabetes was 15 years. The MS appeared after a mean duration of diabetes of 13.7 years. Hypertension was reported in 21 patients (58.3%). The mean BMI was 26 kg/m2. The mean total cholesterol level was 4.59 mmol/l ±1.18, and the mean triglycerides level was 1.67 mmol/l ±0.81. The mean HDL-cholesterol level was 0.96 mmol/l ±0.29. In the majority of cases (80%), MS was the combination of dyslipidemia, hypertension and diabetes. Therapeutically, the average dose of insulin used was 0.8 IU/kg/day. The combination of metformin was necessary in 18 cases (50%). Microvascular complications were present in all patients. The cardiovascular risk was very high in all patients.
The prevalence of MS during T1DM is increasing. It indicates an increased risk of micro and macrovascular complications.
代谢综合征（MS）是2型糖尿病患者心血管风险增加的原因。很少有研究关注1型糖尿病（T1DM）中的MS。
描述受MS影响的T1DM患者的临床、生化和治疗特征。
进行了一项回顾性研究。研究纳入了1997年至2020年期间在突尼斯斯法克斯市赫迪·查克大学医院内分泌 - 糖尿病科住院的36例患有T1DM和MS的患者。MS根据美国国家胆固醇教育计划成人治疗组第三次报告（NCEP - ATP III）标准定义。
患者的平均年龄为53岁。糖尿病的平均病程为15年。MS在糖尿病平均病程13.7年后出现。21例患者（58.3%）报告有高血压。平均体重指数（BMI）为26kg/m²。平均总胆固醇水平为4.59mmol/l±1.18，平均甘油三酯水平为1.67mmol/l±0.81。平均高密度脂蛋白胆固醇（HDL - 胆固醇）水平为0.96mmol/l±0.29。在大多数病例（80%）中，MS是血脂异常、高血压和糖尿病的组合。在治疗方面，所用胰岛素的平均剂量为0.8IU/kg/天。18例患者（50%）需要联合使用二甲双胍。所有患者均存在微血管并发症。所有患者的心血管风险都非常高。
T1DM期间MS的患病率正在增加。这表明微血管和大血管并发症的风险增加。
