抑制跨质膜电子传递：一种潜在的抗白血病策略。
Inhibition of trans-plasma membrane electron transport: a potential anti-leukemic strategy.
机构信息
Department of Biochemistry G. Moruzzi, University of Bologna, Bologna, Italy.
出版信息
Leuk Res. 2010 Dec;34(12):1630-5. doi: 10.1016/j.leukres.2010.02.032. Epub 2010 Mar 24.
The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.
最近的研究表明，糖酵解癌细胞依赖跨质膜电子传递（tPMET）来存活，这引发了一个问题，即 tPMET 是否适合作为抗癌药物开发的靶点。在这项研究中，研究了几种新的和已知的化合物对人髓样白血病细胞系增殖、tPMET 活性和 NAD(P)H 本征荧光的影响。所有数据都证实了 tPMET 在白血病细胞存活中的重要性，并表明这种活性是一个新的潜在的抗白血病靶点。
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