Department of Pharmacology, Medical School, National & Kapodistrian University of Athens, GR-11527, Athens, Greece.
Cancer Genomics Proteomics. 2010 Mar-Apr;7(2):105-9.
Meningiomas are (usually) slow-growing benign tumors, and several factors have been implicated in their development. Increasing age, previous exposure to ionizing radiation, endogenous hormone status and history, hormone replacement therapy, genetic variants and polymorphisms are the main factors that have been proven or assumed to be involved in meningioma formation. The complex genetic background supporting the pathogenesis of meningiomas includes a large number of mutations and polymorphisms that might be actively involved in tumor development, progression and recurrence. The aim of this mini-review is to summarize the current data concerning the role of folate metabolism-related gene polymorphisms in the development of meningiomas.
脑膜瘤（通常）为生长缓慢的良性肿瘤，有多种因素涉及到其发生发展。研究已证实或假设与脑膜瘤形成相关的主要因素包括年龄增长、既往电离辐射暴露、内源性激素状态和病史、激素替代治疗、遗传变异和多态性。支持脑膜瘤发病机制的复杂遗传背景包括大量可能积极参与肿瘤发生、进展和复发的突变和多态性。本文综述了与叶酸代谢相关基因多态性在脑膜瘤发生发展中的作用的现有数据。
