Weikert R J, Bingham S, Emanuel M A, Fraser-Smith E B, Loughhead D G, Nelson P H, Poulton A L
Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
J Med Chem. 1991 May;34(5):1630-3. doi: 10.1021/jm00109a015.
Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a series of benzoylureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2,6-difluoro and 4-trifluoromethyl substituents had potent nematocidal activity in both mice and sheep. No antiectoparasitic activity was observed.
