新型含 1,2,4-三唑部分的砜衍生物的合成与晶体结构。
Synthesis and crystal structure of novel sulfone derivatives containing 1,2,4-triazole moieties.
机构信息
Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, China.
出版信息
Molecules. 2010 Feb 3;15(2):766-79. doi: 10.3390/molecules15020766.
Abstract
Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H2O2. The products were obtained in high yield under mild conditions and practically devoid of any by-products. The structures were confirmed by elemental analysis, IR, 1H- and 13C-NMR spectral data. Furthermore, a detailed X-ray crystallography structural analysis of model triazole 7g was carried out.
摘要
一些 3-(取代甲基硫代)-4-苯基-5-(3,4,5-三甲氧基苯基)-4H-1,2,4-三唑衍生物是从容易获得的没食子酸开始通过六步反应合成的。然后，用 H2O2 将得到的硫醚催化氧化成标题砜。在温和的条件下，以高产率获得了产物，并且几乎没有任何副产物。结构通过元素分析、IR、1H 和 13C-NMR 光谱数据得到确认。此外，还对模型三唑 7g 进行了详细的 X 射线晶体学结构分析。
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