手性钇/钾双金属催化剂催化不对称硝-Mannich 反应。
Catalytic asymmetric nitro-Mannich reactions with a Yb/K heterobimetallic catalyst.
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Molecules. 2010 Mar 4;15(3):1280-90. doi: 10.3390/molecules15031280.
Abstract
A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines.
摘要
一种手性催化不对称硝基曼尼希（aza-Henry）反应，采用稀土金属/碱金属杂双金属催化剂。由酰胺基配体组装的 Yb/K 杂双金属催化剂促进了不对称硝基曼尼希反应，以高达 86%的对映体过量值得到了非对映体过量的反式β-硝基胺。硝基功能的易于还原允许有效地获得光学活性的 1,2-二胺。
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